February 8, 1999
Chronic fatigue syndrome (CFS) or myalgic encephalomyelitis is
a clinically defined syndrome characterized by persistent or
relapsing debilitating fatigue for longer than 6 months in the
absence of any definable medical diagnosis. The cause of this
syndrome is unknown. Symptoms of orthostatic intolerance, such
as disabling fatigue, dizziness, diminished concentration,
tremulousness, and nausea, are often found in patients with
CFS. In this review, we critically evaluate the relationship
between orthostatic intolerance and CFS. Particular emphasis
is placed on clinical diagnosis, laboratory testing,
pathophysiology, and therapeutic management. It is hoped that
this review will provide a stimulus for further study of this
complex and disabling condition.
Schondorf R, Freeman R
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